CJC-1295 is a synthetic analogue of growth hormone-releasing hormone (GHRH) designed to stimulate endogenous growth hormone secretion. It is related structurally to GHRH(1-29), with amino-acid modifications intended to alter its activity and, in the DAC (Drug Affinity Complex) form, extend its circulation time through albumin binding. CJC-1295 has been investigated primarily in growth-hormone physiology and related research. It is not an FDA-approved medication.
Key Points
Drug class: GHRH analogue / growth-hormone secretagogue
Primary action: Stimulates the pituitary to release endogenous growth hormone.
Two commonly discussed forms:CJC-1295 without DAC and CJC-1295 with DAC.
DAC meaning: Drug Affinity Complex; the modified molecule contains an albumin-binding component designed to prolong activity.
Research areas: Growth-hormone secretion, endocrine physiology, and metabolic research.
Clinical status: Investigational and not established as a treatment for muscle growth, fat loss, anti-aging, or athletic performance.
Administration studied: Subcutaneous administration has been evaluated in research.
Safety: Long-term safety and appropriate therapeutic use have not been established.
Regulatory status: No FDA-approved CJC-1295 product is currently established.
Specifications
Name: CJC-1295
Related name: DAC:GRF
Peptide backbone: Modified GHRH(1-29)
Length: 29 amino acids for the DAC-free form; DAC-containing CJC-1295 incorporates an additional modified lysine/DAC group.
CJC-1295 free-base formula:C₁₅₂H₂₅₂N₄₄O₄₂
Free-base molecular weight: Approximately 3,367.95 g/mol.
DAC form formula:C₁₆₅H₂₆₉N₄₇O₄₆
DAC molecular weight: Approximately 3,647.2 g/mol.
CAS:446262-90-4 is listed for the PubChem CJC-1295 structure.
Pharmacological target: GHRH receptor
Approved indication: None
Approved therapeutic dose: None established
Important: CJC-1295 is an investigational peptide, and the terms “CJC-1295,” “CJC-1295 DAC,” and “modified GRF(1-29)” are sometimes used inconsistently. The exact chemical form should therefore be verified when interpreting specifications or research data.
