Pramlintide is a synthetic analogue of the naturally occurring pancreatic hormone amylin. It is used as an adjunct to mealtime insulin in people with type 1 or type 2 diabetes who have not achieved adequate glucose control with optimized insulin therapy. Pramlintide helps regulate blood glucose after meals by slowing gastric emptying, reducing inappropriate glucagon secretion, and increasing feelings of satiety.
Key Points
Drug class: Amylin analogue
Primary use: Adjunctive treatment of diabetes alongside mealtime insulin
Half-life: Approximately 48 minutes in healthy individuals.
Important: Pramlintide requires careful coordination with mealtime insulin and glucose monitoring. Insulin adjustments should be made under appropriate medical supervision because of the risk of severe hypoglycemia.
